Folate:B12
Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
231.605099
|
1
|
<0.0001
|
***
|
|
folate_B12
|
4.066344
|
1
|
0.04
|
*
|
|
Study
|
1.512595
|
1
|
0.2
|
ns
|
|
GA_samp
|
175.975135
|
1
|
<0.0001
|
***
|
|
folate_B12:Study
|
4.357133
|
1
|
0.04
|
*
|
hPL (μg/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
43.8435148
|
1
|
<0.0001
|
***
|
|
folate_B12
|
0.1148209
|
1
|
0.7
|
ns
|
|
Study
|
12.6704561
|
1
|
0.0004
|
***
|
|
GA_samp
|
2499.8832090
|
1
|
<0.0001
|
***
|
|
folate_B12:Study
|
0.1766640
|
1
|
0.7
|
ns
|
GH2 (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
411.4212786
|
1
|
<0.0001
|
***
|
|
folate_B12
|
5.6849187
|
1
|
0.02
|
*
|
|
Study
|
0.2822938
|
1
|
0.6
|
ns
|
|
GA_samp
|
1075.9312193
|
1
|
<0.0001
|
***
|
|
folate_B12:Study
|
0.3248007
|
1
|
0.6
|
ns
|
Insulin (uU/ml)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
folate_B12
|
1
|
Inf
|
0.311
|
0.311
|
0.6
|
ns
|
|
3
|
Study
|
1
|
Inf
|
4.120
|
4.120
|
0.04
|
*
|
|
4
|
GA_samp
|
1
|
Inf
|
1.038
|
1.038
|
0.3
|
ns
|
|
2
|
folate_B12:Study
|
1
|
Inf
|
1.565
|
1.565
|
0.2
|
ns
|
HOMA-IR
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
folate_B12
|
1
|
Inf
|
0.405
|
0.405
|
0.5
|
ns
|
|
3
|
Study
|
1
|
Inf
|
12.419
|
12.419
|
0.0004
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.532
|
0.532
|
0.5
|
ns
|
|
2
|
folate_B12:Study
|
1
|
Inf
|
1.602
|
1.602
|
0.2
|
ns
|
Glucose (mmol/L)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
folate_B12
|
1
|
Inf
|
0.680
|
0.680
|
0.4
|
ns
|
|
3
|
Study
|
1
|
Inf
|
85.551
|
85.551
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.586
|
0.586
|
0.4
|
ns
|
|
2
|
folate_B12:Study
|
1
|
Inf
|
0.108
|
0.108
|
0.7
|
ns
|
Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
15.83 (11.09, 22.58)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.04
|
|
StudySTOP
|
0.93 (0.82, 1.05)
|
0.22
|
|
GA_samp
|
1.15 (1.13, 1.18)
|
<0.0001
|
|
folate_B12:StudySTOP
|
1.00 (1.00, 1.00)
|
0.04
|
hPL (μg/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.87 (1.56, 2.25)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.35
|
|
StudySTOP
|
1.12 (1.06, 1.18)
|
0.0001
|
|
GA_samp
|
1.34 (1.32, 1.36)
|
<0.0001
|
GH2 (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
0.08 (0.06, 0.10)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.004
|
|
StudySTOP
|
0.99 (0.92, 1.07)
|
0.78
|
|
GA_samp
|
1.30 (1.28, 1.32)
|
<0.0001
|
Insulin (uU/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
12.40 (7.86, 19.57)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.50
|
|
StudySTOP
|
0.79 (0.69, 0.92)
|
0.002
|
|
GA_samp
|
1.02 (0.99, 1.05)
|
0.30
|
HOMA-IR
|
Var
|
Effect
|
P
|
|
(Intercept)
|
3.17 (1.96, 5.13)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.46
|
|
StudySTOP
|
0.68 (0.59, 0.80)
|
<0.0001
|
|
GA_samp
|
1.01 (0.98, 1.04)
|
0.45
|
Glucose (mmol/L)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
5.69 (5.21, 6.22)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.37
|
|
StudySTOP
|
0.86 (0.84, 0.88)
|
<0.0001
|
|
GA_samp
|
1.00 (0.99, 1.00)
|
0.45
|
Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
Results are averaged over the levels of Folate:B12 ratio and may be misleading when interaction term is involved.
PRL (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
97.53239
|
7.251682
|
83.62721
|
84.12625
|
113.0749
|
|
STOP
|
96.68844
|
6.873838
|
70.00547
|
83.90659
|
111.4174
|
hPL (μg/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
88.43035
|
2.320844
|
144.0892
|
83.96001
|
93.13872
|
|
STOP
|
98.82664
|
2.377019
|
101.8720
|
94.22247
|
103.65580
|
GH2 (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
2.332928
|
0.0639365
|
389.4782
|
2.210551
|
2.462080
|
|
STOP
|
2.308206
|
0.0528096
|
219.2253
|
2.206439
|
2.414668
|
Insulin (uU/ml)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
14.96949
|
0.7247602
|
Inf
|
13.61430
|
16.45958
|
|
STOP
|
11.89513
|
0.4308389
|
Inf
|
11.07997
|
12.77025
|
HOMA-IR
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
3.637941
|
0.1871675
|
Inf
|
3.288988
|
4.023916
|
|
STOP
|
2.490395
|
0.0951873
|
Inf
|
2.310648
|
2.684124
|
Glucose (mmol/L)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
5.496623
|
0.0508714
|
Inf
|
5.397816
|
5.597239
|
|
STOP
|
4.729527
|
0.0347387
|
Inf
|
4.661929
|
4.798107
|
Comparisons
Effect for every 100 unit increase in Folate:B12 ratio.
|
Hormone
|
Contrast
|
Study
|
Ratio of Geometric means (95% CI)
|
P-value
|
|
PRL (ng/ml)
|
folate_B12245.96 / folate_B12145.96
|
SCOPE
|
0.98 (0.95, 1.00)
|
0.04
|
|
PRL (ng/ml)
|
folate_B12245.96 / folate_B12145.96
|
STOP
|
1.01 (0.99, 1.03)
|
0.4
|
|
hPL (μg/ml)
|
folate_B12245.96 / folate_B12145.96
|
SCOPE
|
1.00 (0.99, 1.00)
|
0.4
|
|
hPL (μg/ml)
|
folate_B12245.96 / folate_B12145.96
|
STOP
|
1.00 (0.99, 1.00)
|
0.4
|
|
GH2 (ng/ml)
|
folate_B12245.96 / folate_B12145.96
|
SCOPE
|
0.98 (0.97, 0.99)
|
0.004
|
|
GH2 (ng/ml)
|
folate_B12245.96 / folate_B12145.96
|
STOP
|
0.98 (0.97, 0.99)
|
0.004
|
|
Insulin (uU/ml)
|
folate_B12245.96 / folate_B12145.96
|
SCOPE
|
0.99 (0.97, 1.01)
|
0.5
|
|
Insulin (uU/ml)
|
folate_B12245.96 / folate_B12145.96
|
STOP
|
0.99 (0.97, 1.01)
|
0.5
|
|
HOMA-IR
|
folate_B12245.96 / folate_B12145.96
|
SCOPE
|
0.99 (0.97, 1.01)
|
0.5
|
|
HOMA-IR
|
folate_B12245.96 / folate_B12145.96
|
STOP
|
0.99 (0.97, 1.01)
|
0.5
|
|
Glucose (mmol/L)
|
folate_B12245.96 / folate_B12145.96
|
SCOPE
|
1.00 (0.99, 1.00)
|
0.4
|
|
Glucose (mmol/L)
|
folate_B12245.96 / folate_B12145.96
|
STOP
|
1.00 (0.99, 1.00)
|
0.4
|
Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)
Diagnositcs for hPL (μg/ml)
Diagnositcs for GH2 (ng/ml)
Diagnositcs for Insulin (uU/ml)
Diagnositcs for HOMA-IR
Diagnositcs for Glucose (mmol/L)
